Expression of DGAT1 in cancer - Summary

CANCER ATLAS

Gene description

Diacylglycerol O-acyltransferase 1

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB032853

GENE INFORMATION
Gene name	DGAT1 (HGNC Symbol)
Synonyms	ARGP1, DGAT
Description	Diacylglycerol O-acyltransferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144314584 - 144326910
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185000 (version 83.38)
Entrez gene	8694
UniProt	O75907 (UniProt - Evidence at protein level)
neXtProt	NX_O75907
Antibodypedia	DGAT1 antibodies

PROTEIN BROWSER

DGAT1-001	DGAT1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DGAT1-001 ENSP00000482264 ENST00000528718	O75907 [Direct mapping] Diacylglycerol O-acyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003846 [2-acylglycerol O-acyltransferase activity] GO:0004144 [diacylglycerol O-acyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006641 [triglyceride metabolic process] GO:0006644 [phospholipid metabolic process] GO:0008374 [O-acyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0019915 [lipid storage] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0036155 [acylglycerol acyl-chain remodeling] GO:0042572 [retinol metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046339 [diacylglycerol metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0050252 [retinol O-fatty-acyltransferase activity] GO:0055089 [fatty acid homeostasis] Show all	488 aa 55.3 kDa	No	8
DGAT1-004 ENSP00000332258 ENST00000332324	A0A0A0MR74 [Direct mapping] Diacylglycerol O-acyltransferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0008152 [metabolic process] GO:0008374 [O-acyltransferase activity] GO:0016021 [integral component of membrane] Show all	315 aa 33.5 kDa	No	4