Tissue expression of ROBO2 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ROBO2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ROBO2
Gene description	Roundabout guidance receptor 2
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (caudate, cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA013371
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, cerebellum)

GENE INFORMATION
Gene name	ROBO2 (HGNC Symbol)
Synonyms	KIAA1568
Description	Roundabout guidance receptor 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	3
Cytoband	p12.3
Chromosome location (bp)	75906695 - 77649964
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185008 (version 83.38)
Entrez gene	6092
UniProt	Q9HCK4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCK4
Antibodypedia	ROBO2 antibodies

PROTEIN BROWSER

ROBO2-001	ROBO2-002	ROBO2-003	ROBO2-004	ROBO2-008	ROBO2-010	ROBO2-012	ROBO2-013	ROBO2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ROBO2-001 ENSP00000473268 ENST00000602589	R4GMM8 [Direct mapping] Roundabout homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1070 aa 117.9 kDa	No	1
ROBO2-002 ENSP00000417164 ENST00000461745	Q9HCK4 [Direct mapping] Roundabout homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001656 [metanephros development] GO:0001657 [ureteric bud development] GO:0005515 [protein binding] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0008046 [axon guidance receptor activity] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016199 [axon midline choice point recognition] GO:0021891 [olfactory bulb interneuron development] GO:0030673 [axolemma] GO:0031290 [retinal ganglion cell axon guidance] GO:0032870 [cellular response to hormone stimulus] GO:0042802 [identical protein binding] GO:0050772 [positive regulation of axonogenesis] GO:0050925 [negative regulation of negative chemotaxis] GO:0051964 [negative regulation of synapse assembly] GO:0061364 [apoptotic process involved in luteolysis] GO:0070062 [extracellular exosome] Show all	1378 aa 151.2 kDa	Yes	1
ROBO2-003 ENSP00000327536 ENST00000332191	F8W703 [Direct mapping] Roundabout homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1439 aa 157.4 kDa	Yes	1
ROBO2-004 ENSP00000418344 ENST00000490991	H7C4V8 [Direct mapping] Roundabout homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	342 aa 37.2 kDa	No	1
ROBO2-008 ENSP00000417471 ENST00000490534	H7C4J7 [Direct mapping] Roundabout homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 21.3 kDa	No	0
ROBO2-010 ENSP00000418190 ENST00000471893	H7C4U9 [Direct mapping] Roundabout homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		215 aa 23 kDa	No	0
ROBO2-012 ENSP00000418446 ENST00000475334	H7C4W9 [Direct mapping] Roundabout homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		208 aa 22.3 kDa	No	0
ROBO2-013 ENSP00000417335 ENST00000487694	Q9HCK4 [Direct mapping] Roundabout homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001656 [metanephros development] GO:0001657 [ureteric bud development] GO:0005515 [protein binding] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0008046 [axon guidance receptor activity] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016199 [axon midline choice point recognition] GO:0021891 [olfactory bulb interneuron development] GO:0030673 [axolemma] GO:0031290 [retinal ganglion cell axon guidance] GO:0032870 [cellular response to hormone stimulus] GO:0042802 [identical protein binding] GO:0050772 [positive regulation of axonogenesis] GO:0050925 [negative regulation of negative chemotaxis] GO:0051964 [negative regulation of synapse assembly] GO:0061364 [apoptotic process involved in luteolysis] GO:0070062 [extracellular exosome] Show all	1394 aa 153.1 kDa	No	1
ROBO2-201 ENSP00000480344 ENST00000614793	A0A087WWM5 [Direct mapping] Roundabout homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1250 aa 136.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.