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MAFF

CANCER ATLAS

Gene description

 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F

Protein class

 Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB025341

GENE INFORMATION

Gene name

 MAFF (HGNC Symbol)

Synonyms

 hMafF

Description

 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 38200767 - 38216511

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185022 (version 83.38)

Entrez gene

 23764

UniProt

 Q9ULX9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULX9

Antibodypedia

 MAFF antibodies

PROTEIN BROWSER
MAFF-001
MAFF-002
MAFF-003
MAFF-004
MAFF-201
MAFF-202
MAFF-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAFF-001
ENSP00000345393
ENST00000338483
Q9ULX9 [Direct mapping]
Transcription factor MafF
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007567 [parturition]
GO:0007596 [blood coagulation]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045604 [regulation of epidermal cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 164 aa
17.8 kDa 		No 0
MAFF-002
ENSP00000384094
ENST00000407965
Q9ULX9 [Direct mapping]
Transcription factor MafF
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007567 [parturition]
GO:0007596 [blood coagulation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 164 aa
17.8 kDa 		No 0
MAFF-003
ENSP00000416493
ENST00000417948
B0QY70 [Direct mapping]
Transcription factor MafF
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 126 aa
14.3 kDa 		No 0
MAFF-004
ENSP00000391589
ENST00000441709
B0QY71 [Direct mapping]
Transcription factor MafF
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 93 aa
10.7 kDa 		No 0
MAFF-201
ENSP00000388882
ENST00000426621
Q9ULX9 [Direct mapping]
Transcription factor MafF
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007567 [parturition]
GO:0007596 [blood coagulation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 164 aa
17.8 kDa 		No 0
MAFF-202
ENSP00000442060
ENST00000538320
Q9ULX9 [Direct mapping]
Transcription factor MafF
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007567 [parturition]
GO:0007596 [blood coagulation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 164 aa
17.8 kDa 		No 0
MAFF-203
ENSP00000441482
ENST00000538999
Q9ULX9 [Direct mapping]
Transcription factor MafF
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007567 [parturition]
GO:0007596 [blood coagulation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 135 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.