Cell atlas - ANKS1B - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ANKS1B
Gene description	Ankyrin repeat and sterile alpha motif domain containing 1B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	21
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to vesicles.
RNA cell category	Cell line enhanced (SCLC-21H, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044628
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to vesicles.

Main location

Plasma membrane (approved), Cytosol (approved)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA044628	A549	Vesicles
		Plasma membrane
		Cytosol
HPA044628	U-2 OS	Plasma membrane
HPA044628	U-2 OS	Cytosol

GENE INFORMATION
Gene name	ANKS1B (HGNC Symbol)
Synonyms	AIDA-1, ANKS2, cajalin-2, EB-1
Description	Ankyrin repeat and sterile alpha motif domain containing 1B (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
Chromosome	12
Cytoband	q23.1
Chromosome location (bp)	98726457 - 99984654
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185046 (version 83.38)
Entrez gene	56899
UniProt	Q7Z6G8 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z6G8
Antibodypedia	ANKS1B antibodies

PROTEIN BROWSER

ANKS1B-001	ANKS1B-002	ANKS1B-003	ANKS1B-004	ANKS1B-005	ANKS1B-006	ANKS1B-008	ANKS1B-009	ANKS1B-010	ANKS1B-011	ANKS1B-012	ANKS1B-013	ANKS1B-015	ANKS1B-016	ANKS1B-024	ANKS1B-025	ANKS1B-026	ANKS1B-027	ANKS1B-028	ANKS1B-032	ANKS1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKS1B-001 ENSP00000449894 ENST00000549866	F8VVQ4 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	563 aa 61.2 kDa	No	0
ANKS1B-002 ENSP00000448512 ENST00000547010	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	764 aa 85.2 kDa	No	0
ANKS1B-003 ENSP00000449629 ENST00000547776	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] GO:1900383 [regulation of synaptic plasticity by receptor localization to synapse] Show all	1248 aa 138.1 kDa	No	0
ANKS1B-004 ENSP00000450015 ENST00000547446	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	394 aa 44.5 kDa	No	0
ANKS1B-005 ENSP00000447312 ENST00000549025	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	357 aa 40.3 kDa	No	0
ANKS1B-006 ENSP00000331256 ENST00000333732	F8VR14 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	289 aa 32.8 kDa	No	0
ANKS1B-008 ENSP00000448744 ENST00000550778	H0YI72 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	532 aa 59.9 kDa	No	0
ANKS1B-009 ENSP00000448203 ENST00000549493	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	510 aa 57.9 kDa	No	0
ANKS1B-010 ENSP00000473522 ENST00000546364	R4GN78 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	151 aa 17.3 kDa	No	0
ANKS1B-011 ENSP00000448993 ENST00000549558	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	414 aa 47.1 kDa	No	0
ANKS1B-012 ENSP00000447999 ENST00000550693	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	450 aa 51.1 kDa	No	0
ANKS1B-013 ENSP00000447839 ENST00000546960	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	460 aa 52.3 kDa	No	0
ANKS1B-015 ENSP00000448205 ENST00000546568	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	426 aa 48.4 kDa	No	0
ANKS1B-016 ENSP00000345510 ENST00000341752	Q7Z6G8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0014069 [postsynaptic density] GO:0015030 [Cajal body] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0046875 [ephrin receptor binding] Show all	254 aa 28.9 kDa	No	0
ANKS1B-024 ENSP00000473673 ENST00000551560	R4GNJ0 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.5 kDa	No	0
ANKS1B-025 ENSP00000473434 ENST00000552748	R4GN07 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.6 kDa	No	0
ANKS1B-026 ENSP00000473331 ENST00000552407	R4GMS8 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 11.2 kDa	No	0
ANKS1B-027 ENSP00000473513 ENST00000551613	R4GN70 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 2.3 kDa	No	0
ANKS1B-028 ENSP00000473517 ENST00000548447	R4GN73 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		27 aa 3.4 kDa	No	0
ANKS1B-032 ENSP00000473300 ENST00000549797	R4GMQ4 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 10.8 kDa	No	0
ANKS1B-201 ENSP00000331381 ENST00000329257	J3QSU0 [Direct mapping] Ankyrin repeat and sterile alpha motif domain-containing protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	332 aa 36.5 kDa	No	0