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Several pancreatic and liver cancers displayed moderate cytoplasmic and nuclear positivity. Most other malignancies showed several cases of weak cytoplasmic staining. Malignant lymphomas and gliomas were negative.
Squamous cell carcinomas, basal cell carcinomas and a few cases of urothelial and pancreatic cancers exhibited moderate positivity. Virtually no staining in other malignancies.
GENE INFORMATION
Gene name
KRT76 (HGNC Symbol)
Synonyms
HUMCYT2A, KRT2B, KRT2P
Description
Keratin 76, type II (HGNC Symbol)
Entrez gene summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009]