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ADSSL1

GENERAL INFORMATION

Gene name

 ADSSL1

Gene description

 Adenylosuccinate synthase like 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Expressed in all
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 ADSSL1 (HGNC Symbol)

Synonyms

 FLJ38602

Description

 Adenylosuccinate synthase like 1 (HGNC Symbol)

Entrez gene summary

 ADSSL1 is a muscle isozyme of adenylosuccinate synthase (EC 6.3.4.4), which catalyzes the initial reaction in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP) (Sun et al., 2005 [PubMed 15786719]).[supplied by OMIM, Dec 2008]

Chromosome

 14

Cytoband

 q32.33

Chromosome location (bp)

 104724186 - 104747325

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185100 (version 83.38)

Entrez gene

 122622

UniProt

 Q8N142 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N142

Antibodypedia

 ADSSL1 antibodies

PROTEIN BROWSER
ADSSL1-001
ADSSL1-002
ADSSL1-010
ADSSL1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADSSL1-001
ENSP00000331260
ENST00000330877
Q8N142 [Direct mapping]
Adenylosuccinate synthetase isozyme 1
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002376 [immune system process]
GO:0004019 [adenylosuccinate synthase activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006167 [AMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0042301 [phosphate ion binding]
GO:0044208 ['de novo' AMP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046040 [IMP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 457 aa
50.2 kDa 		No 0
ADSSL1-002
ENSP00000333019
ENST00000332972
Q8N142 [Direct mapping]
Adenylosuccinate synthetase isozyme 1
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002376 [immune system process]
GO:0003924 [GTPase activity]
GO:0004019 [adenylosuccinate synthase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006163 [purine nucleotide metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006167 [AMP biosynthetic process]
GO:0006531 [aspartate metabolic process]
GO:0006541 [glutamine metabolic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0014850 [response to muscle activity]
GO:0035690 [cellular response to drug]
GO:0042301 [phosphate ion binding]
GO:0042594 [response to starvation]
GO:0042803 [protein homodimerization activity]
GO:0044208 ['de novo' AMP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046040 [IMP metabolic process]
GO:0051015 [actin filament binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071257 [cellular response to electrical stimulus]
Show all
 500 aa
54.6 kDa 		No 0
ADSSL1-010
ENSP00000450433
ENST00000555674
G3V232 [Direct mapping]
Adenylosuccinate synthetase isozyme 1
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004019 [adenylosuccinate synthase activity]
GO:0005525 [GTP binding]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0044208 ['de novo' AMP biosynthetic process]
GO:0046040 [IMP metabolic process]
Show all
 74 aa
8.4 kDa 		No 0
ADSSL1-011
ENSP00000452303
ENST00000556623
G3V5D8 [Direct mapping]
Adenylosuccinate synthetase isozyme 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004019 [adenylosuccinate synthase activity]
GO:0005525 [GTP binding]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0044208 ['de novo' AMP biosynthetic process]
GO:0046040 [IMP metabolic process]
Show all
 63 aa
7.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.