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MIXL1

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GENERAL INFORMATION

Gene name

 MIXL1

Gene description

 Mix paired-like homeobox

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Cell line enhanced (Hep G2, U-698)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA005662
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, U-698)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA005662 Hep G2 Nucleus Intensity

GENE INFORMATION

Gene name

 MIXL1 (HGNC Symbol)

Synonyms

 MILD1, MIXL

Description

 Mix paired-like homeobox (HGNC Symbol)

Entrez gene summary

 Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008]

Chromosome

 1

Cytoband

 q42.12

Chromosome location (bp)

 226223618 - 226227054

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185155 (version 83.38)

Entrez gene

 83881

UniProt

 Q9H2W2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2W2

Antibodypedia

 MIXL1 antibodies

PROTEIN BROWSER
MIXL1-001
MIXL1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MIXL1-001
ENSP00000355775
ENST00000366810
Q9H2W2 [Direct mapping]
Homeobox protein MIXL1
A0A024R3T7 [Target identity:100%; Query identity:100%]
Mix1 homeobox-like 1 (Xenopus laevis), isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007369 [gastrulation]
GO:0007492 [endoderm development]
GO:0007507 [heart development]
GO:0035987 [endodermal cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048565 [digestive tract development]
GO:1901533 [negative regulation of hematopoietic progenitor cell differentiation]
GO:2000382 [positive regulation of mesoderm development]
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 232 aa
24.7 kDa 		No 0
MIXL1-002
ENSP00000442439
ENST00000542034
Q9H2W2 [Direct mapping]
Homeobox protein MIXL1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001706 [endoderm formation]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007369 [gastrulation]
GO:0007492 [endoderm development]
GO:0007507 [heart development]
GO:0030097 [hemopoiesis]
GO:0035987 [endodermal cell differentiation]
GO:0042074 [cell migration involved in gastrulation]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048565 [digestive tract development]
GO:1901533 [negative regulation of hematopoietic progenitor cell differentiation]
GO:2000382 [positive regulation of mesoderm development]
Show all
 240 aa
25.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.