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RAB11B

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GENERAL INFORMATION

Gene name

 RAB11B

Gene description

 RAB11B, member RAS oncogene family

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the microtubule organizing center & vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved), Microtubule organizing center (approved)

Mouse

 Localized to the Vesicles, Microtubule organizing center in mouse cells.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA054396
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the microtubule organizing center & vesicles.

Main location

 Vesicles (approved), Microtubule organizing center (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA054396 A-431 Vesicles
Microtubule organizing center
HPA054396 HeLa Vesicles
Microtubule organizing center
HPA054396 U-2 OS Vesicles
Microtubule organizing center

MOUSE CELLS

Main location

 Vesicles, Microtubule organizing center

Mouse gene

 ENSMUSG00000077450 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA054396 NIH 3T3 Vesicles
Microtubule organizing center

GENE INFORMATION

Gene name

 RAB11B (HGNC Symbol)

Synonyms

 H-YPT3

Description

 RAB11B, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 8389981 - 8404434

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185236 (version 83.38)

Entrez gene

 9230

UniProt

 Q15907 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15907

Antibodypedia

 RAB11B antibodies

PROTEIN BROWSER
RAB11B-001
RAB11B-002
RAB11B-004
RAB11B-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB11B-001
ENSP00000333547
ENST00000328024
Q15907 [Direct mapping]
Ras-related protein Rab-11B
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001881 [receptor recycling]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008021 [synaptic vesicle]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019003 [GDP binding]
GO:0030054 [cell junction]
GO:0030670 [phagocytic vesicle membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0031489 [myosin V binding]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0033572 [transferrin transport]
GO:0035773 [insulin secretion involved in cellular response to glucose stimulus]
GO:0044070 [regulation of anion transport]
GO:0045054 [constitutive secretory pathway]
GO:0045055 [regulated secretory pathway]
GO:0045335 [phagocytic vesicle]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0071468 [cellular response to acidic pH]
GO:0090150 [establishment of protein localization to membrane]
GO:1990126 [retrograde transport, endosome to plasma membrane]
GO:2000008 [regulation of protein localization to cell surface]
GO:2001135 [regulation of endocytic recycling]
Show all
 218 aa
24.5 kDa 		No 0
RAB11B-002
ENSP00000471148
ENST00000594216
Q15907 [Direct mapping]
Ras-related protein Rab-11B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001881 [receptor recycling]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008021 [synaptic vesicle]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030054 [cell junction]
GO:0030670 [phagocytic vesicle membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0031489 [myosin V binding]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0033572 [transferrin transport]
GO:0035773 [insulin secretion involved in cellular response to glucose stimulus]
GO:0044070 [regulation of anion transport]
GO:0045054 [constitutive secretory pathway]
GO:0045055 [regulated secretory pathway]
GO:0045335 [phagocytic vesicle]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0071468 [cellular response to acidic pH]
GO:0090150 [establishment of protein localization to membrane]
GO:1990126 [retrograde transport, endosome to plasma membrane]
GO:2000008 [regulation of protein localization to cell surface]
GO:2001135 [regulation of endocytic recycling]
Show all
 179 aa
20 kDa 		No 0
RAB11B-004
ENSP00000473042
ENST00000600719
M0R377 [Direct mapping]
Ras-related protein Rab-11B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0045055 [regulated secretory pathway]
GO:0055037 [recycling endosome]
Show all
 46 aa
5.1 kDa 		No 0
RAB11B-005
ENSP00000472473
ENST00000601897
M0R2D0 [Direct mapping]
Ras-related protein Rab-11B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0045055 [regulated secretory pathway]
GO:0055037 [recycling endosome]
Show all
 60 aa
6.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.