We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Colorectal cancers displayed strong staining of the cytoplasm. Cancer cells generally displayed moderate immunoreactivity. A majority of lymphomas, gastric and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SOCS1 (HGNC Symbol)
Synonyms
Cish1, JAB, SOCS-1, SSI-1, TIP3
Description
Suppressor of cytokine signaling 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]