Tissue expression of PDE6G - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PDE6G
Gene description	Phosphodiesterase 6G, cGMP-specific, rod, gamma
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen, lymph node)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, lymph node)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	PDE6G (HGNC Symbol)
Synonyms	PDEG, RP57
Description	Phosphodiesterase 6G, cGMP-specific, rod, gamma (HGNC Symbol)
Entrez gene summary	This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81650459 - 81663112
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185527 (version 83.38)
Entrez gene	5148
UniProt	P18545 (UniProt - Evidence at protein level)
neXtProt	NX_P18545
Antibodypedia	PDE6G antibodies

PROTEIN BROWSER

PDE6G-001	PDE6G-002	PDE6G-003	PDE6G-005	PDE6G-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE6G-001 ENSP00000461464 ENST00000571004	P18545 [Direct mapping] Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008152 [metabolic process] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030553 [cGMP binding] GO:0043086 [negative regulation of catalytic activity] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] GO:0097381 [photoreceptor disc membrane] Show all	87 aa 9.6 kDa	No	0
PDE6G-002 ENSP00000458567 ENST00000573076	A0A0C4DGN0 [Direct mapping] Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Show all	Predicted intracellular proteins Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007601 [visual perception] GO:0008152 [metabolic process] GO:0030553 [cGMP binding] Show all	137 aa 15.1 kDa	No	0
PDE6G-003 ENSP00000460962 ENST00000574024	I3L446 [Direct mapping] Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Show all	Predicted intracellular proteins Show all		70 aa 7.5 kDa	No	0
PDE6G-005 ENSP00000458167 ENST00000571224	P18545 [Direct mapping] Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008152 [metabolic process] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030553 [cGMP binding] GO:0043086 [negative regulation of catalytic activity] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] GO:0097381 [photoreceptor disc membrane] Show all	87 aa 9.6 kDa	No	0
PDE6G-201 ENSP00000328412 ENST00000331056	P18545 [Direct mapping] Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008152 [metabolic process] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030507 [spectrin binding] GO:0030553 [cGMP binding] GO:0043086 [negative regulation of catalytic activity] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] GO:0097381 [photoreceptor disc membrane] Show all	87 aa 9.6 kDa	No	0