Expression of LMLN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Leishmanolysin-like (metallopeptidase M8 family)

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA016481	HPA028844

GENE INFORMATION
Gene name	LMLN (HGNC Symbol)
Synonyms	Gp63, Msp
Description	Leishmanolysin-like (metallopeptidase M8 family) (HGNC Symbol)
Entrez gene summary	This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	197960200 - 198043720
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185621 (version 83.38)
Entrez gene	89782
UniProt	Q96KR4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96KR4
Antibodypedia	LMLN antibodies

PROTEIN BROWSER

LMLN-001	LMLN-002	LMLN-004	LMLN-005	LMLN-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LMLN-001 ENSP00000328829 ENST00000330198	Q96KR4 [Direct mapping] Leishmanolysin-like peptidase Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005737 [cytoplasm] GO:0005811 [lipid particle] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0007067 [mitotic nuclear division] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0046872 [metal ion binding] GO:0051301 [cell division] Show all	655 aa 73.6 kDa	No	1
LMLN-002 ENSP00000418324 ENST00000482695	Q96KR4 [Direct mapping] Leishmanolysin-like peptidase Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005737 [cytoplasm] GO:0005811 [lipid particle] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0007067 [mitotic nuclear division] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0046872 [metal ion binding] GO:0051301 [cell division] Show all	640 aa 72.8 kDa	No	1
LMLN-004 ENSP00000410926 ENST00000420910	Q96KR4 [Direct mapping] Leishmanolysin-like peptidase Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005737 [cytoplasm] GO:0005811 [lipid particle] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0007067 [mitotic nuclear division] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0046872 [metal ion binding] GO:0051301 [cell division] Show all	692 aa 78.1 kDa	No	1
LMLN-005 ENSP00000328611 ENST00000332636	F8WCE5 [Direct mapping] Leishmanolysin-like peptidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	603 aa 68.2 kDa	No	1
LMLN-006 ENSP00000390872 ENST00000419117	C9JF40 [Direct mapping] Leishmanolysin-like peptidase Show all	Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	151 aa 17.2 kDa	No	0