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NTF3

CANCER ATLAS

Gene description

 Neurotrophin 3

Protein class

 Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA032001

GENE INFORMATION

Gene name

 NTF3 (HGNC Symbol)

Synonyms

 NGF2

Description

 Neurotrophin 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 5432112 - 5521536

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185652 (version 83.38)

Entrez gene

 4908

UniProt

 P20783 (UniProt - Evidence at protein level)

neXtProt

 NX_P20783

Antibodypedia

 NTF3 antibodies

PROTEIN BROWSER
NTF3-001
NTF3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NTF3-001
ENSP00000397297
ENST00000423158
P20783 [Direct mapping]
Neurotrophin-3
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000187 [activation of MAPK activity]
GO:0002092 [positive regulation of receptor internalization]
GO:0005102 [receptor binding]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007274 [neuromuscular synaptic transmission]
GO:0007399 [nervous system development]
GO:0007403 [glial cell fate determination]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007422 [peripheral nervous system development]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0021675 [nerve development]
GO:0030335 [positive regulation of cell migration]
GO:0032148 [activation of protein kinase B activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042056 [chemoattractant activity]
GO:0042490 [mechanoreceptor differentiation]
GO:0042552 [myelination]
GO:0042981 [regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0045687 [positive regulation of glial cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048406 [nerve growth factor binding]
GO:0048484 [enteric nervous system development]
GO:0048666 [neuron development]
GO:0048699 [generation of neurons]
GO:0048812 [neuron projection morphogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [modulation of synaptic transmission]
GO:0050918 [positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051145 [smooth muscle cell differentiation]
GO:0090630 [activation of GTPase activity]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 270 aa
30.8 kDa 		No 0
NTF3-002
ENSP00000328738
ENST00000331010
P20783 [Direct mapping]
Neurotrophin-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000187 [activation of MAPK activity]
GO:0002092 [positive regulation of receptor internalization]
GO:0005102 [receptor binding]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030335 [positive regulation of cell migration]
GO:0032148 [activation of protein kinase B activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042056 [chemoattractant activity]
GO:0042981 [regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045664 [regulation of neuron differentiation]
GO:0048812 [neuron projection morphogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0090630 [activation of GTPase activity]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 257 aa
29.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.