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Malignant cells generally displayed moderate cytopalsmic staining. Renal cancers, malignant gliomas, lymphomas and skin cancers were weakly stained or negative. Cholangiocarcinomas were strongly immunoreactive.
GENE INFORMATION
Gene name
SNAI3 (HGNC Symbol)
Synonyms
SMUC, Zfp293, ZNF293
Description
Snail family zinc finger 3 (HGNC Symbol)
Entrez gene summary
SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005507 [copper ion binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
