Tissue expression of PRAME - Summary - The Human Protein Atlas

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PRAME

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PRAME
Gene description	Preferentially expressed antigen in melanoma
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (testis, epididymis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in seminiferous ducts in testis.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA045153
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	PRAME (HGNC Symbol)
Synonyms	CT130, MAPE
Description	Preferentially expressed antigen in melanoma (HGNC Symbol)
Entrez gene summary	This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Chromosome	22
Cytoband	q11.22
Chromosome location (bp)	22547701 - 22559361
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185686 (version 83.38)
Entrez gene	23532
UniProt	P78395 (UniProt - Evidence at protein level)
neXtProt	NX_P78395
Antibodypedia	PRAME antibodies

PROTEIN BROWSER

PRAME-001	PRAME-003	PRAME-004	PRAME-005	PRAME-006	PRAME-008	PRAME-009	PRAME-012	PRAME-201	PRAME-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRAME-001 ENSP00000381728 ENST00000398743	P78395 [Direct mapping] Melanoma antigen preferentially expressed in tumors A0A024R1E6 [Target identity:100%; Query identity:100%] Preferentially expressed antigen in melanoma, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0008284 [positive regulation of cell proliferation] GO:0030154 [cell differentiation] GO:0040008 [regulation of growth] GO:0042974 [retinoic acid receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0045596 [negative regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] Show all	509 aa 57.9 kDa	No	0
PRAME-003 ENSP00000385198 ENST00000402697	P78395 [Direct mapping] Melanoma antigen preferentially expressed in tumors A0A024R1E6 [Target identity:100%; Query identity:100%] Preferentially expressed antigen in melanoma, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0008284 [positive regulation of cell proliferation] GO:0030154 [cell differentiation] GO:0040008 [regulation of growth] GO:0042974 [retinoic acid receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0045596 [negative regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] Show all	509 aa 57.9 kDa	No	0
PRAME-004 ENSP00000384343 ENST00000405655	P78395 [Direct mapping] Melanoma antigen preferentially expressed in tumors A0A024R1E6 [Target identity:100%; Query identity:100%] Preferentially expressed antigen in melanoma, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0008284 [positive regulation of cell proliferation] GO:0030154 [cell differentiation] GO:0040008 [regulation of growth] GO:0042974 [retinoic acid receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0045596 [negative regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] Show all	509 aa 57.9 kDa	No	0
PRAME-005 ENSP00000407320 ENST00000439106	E7EW99 [Direct mapping] Melanoma antigen preferentially-expressed in tumors Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		201 aa 23.1 kDa	No	0
PRAME-006 ENSP00000384058 ENST00000406503	B5MCY4 [Direct mapping] Melanoma antigen preferentially-expressed in tumors Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.1 kDa	No	0
PRAME-008 ENSP00000412318 ENST00000420709	E7EMH2 [Direct mapping] Melanoma antigen preferentially-expressed in tumors Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 17.5 kDa	No	0
PRAME-009 ENSP00000385091 ENST00000403441	B5MD04 [Direct mapping] Melanoma antigen preferentially-expressed in tumors Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.8 kDa	No	0
PRAME-012 ENSP00000407121 ENST00000438888	H7C2P3 [Direct mapping] Melanoma antigen preferentially-expressed in tumors Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		189 aa 21.1 kDa	No	0
PRAME-201 ENSP00000381726 ENST00000398741	P78395 [Direct mapping] Melanoma antigen preferentially expressed in tumors A0A024R1E6 [Target identity:100%; Query identity:100%] Preferentially expressed antigen in melanoma, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0008284 [positive regulation of cell proliferation] GO:0030154 [cell differentiation] GO:0040008 [regulation of growth] GO:0042974 [retinoic acid receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0045596 [negative regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] Show all	509 aa 57.9 kDa	No	0
PRAME-202 ENSP00000445675 ENST00000543184	P78395 [Direct mapping] Melanoma antigen preferentially expressed in tumors A0A024R1E6 [Target identity:100%; Query identity:100%] Preferentially expressed antigen in melanoma, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0008284 [positive regulation of cell proliferation] GO:0030154 [cell differentiation] GO:0040008 [regulation of growth] GO:0042974 [retinoic acid receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0045596 [negative regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] Show all	509 aa 57.9 kDa	No	0

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