Cell atlas - YTHDF3 - The Human Protein Atlas

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YTHDF3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear membrane
	Nuclear speckles

Human cell
	Cytosol
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	YTHDF3
Gene description	YTH N(6)-methyladenosine RNA binding protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the nuclear membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)
Additional location	In addition localized to the Nuclear membrane (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048703
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the nuclear membrane & cytosol.

Main location

Nuclear speckles (approved)

Additional location

Nuclear membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048703	SK-MEL-30	Nuclear membrane	Intensity
			Nuclear speckles	Intensity
			Cytosol
	HPA048703	SiHa	Nuclear speckles
	HPA048703	SiHa	Mitochondria

GENE INFORMATION
Gene name	YTHDF3 (HGNC Symbol)
Synonyms	FLJ31657
Description	YTH N(6)-methyladenosine RNA binding protein 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Chromosome	8
Cytoband	q12.3
Chromosome location (bp)	63168553 - 63212786
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185728 (version 83.38)
Entrez gene	253943
UniProt	Q7Z739 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z739
Antibodypedia	YTHDF3 antibodies

PROTEIN BROWSER

YTHDF3-001	YTHDF3-002	YTHDF3-005	YTHDF3-006	YTHDF3-008	YTHDF3-010	YTHDF3-011	YTHDF3-012	YTHDF3-014	YTHDF3-015	YTHDF3-201	YTHDF3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
YTHDF3-001 ENSP00000473496 ENST00000539294	Q7Z739 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0044822 [poly(A) RNA binding] GO:1990247 [N6-methyladenosine-containing RNA binding] Show all	585 aa 63.9 kDa	No	0
YTHDF3-002 ENSP00000481476 ENST00000621820	A0A087WY31 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		588 aa 64.5 kDa	No	0
YTHDF3-005 ENSP00000478356 ENST00000617952	A0A087WU40 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		86 aa 9.6 kDa	No	0
YTHDF3-006 ENSP00000478825 ENST00000621890	A0A024R7W5 [Direct mapping] YTH domain family, member 3, isoform CRA_a; YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		534 aa 58.3 kDa	No	0
YTHDF3-008 ENSP00000480086 ENST00000612880	A0A087WWB0 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		112 aa 11.9 kDa	No	0
YTHDF3-010 ENSP00000473986 ENST00000517371	S4R373 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		52 aa 5.8 kDa	No	0
YTHDF3-011 ENSP00000478398 ENST00000619337	A0A087WU63 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		102 aa 10.9 kDa	No	0
YTHDF3-012 ENSP00000483659 ENST00000613853	A0A087X0U5 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		119 aa 13.2 kDa	No	0
YTHDF3-014 ENSP00000478490 ENST00000621413	A0A087WY31 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		588 aa 64.5 kDa	No	0
YTHDF3-015 ENSP00000483580 ENST00000621957	A0A087X0Q1 [Direct mapping] YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		583 aa 63.7 kDa	No	0
YTHDF3-201 ENSP00000481497 ENST00000617200	A0A024R7W5 [Direct mapping] YTH domain family, member 3, isoform CRA_a; YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		534 aa 58.3 kDa	No	0
YTHDF3-202 ENSP00000485046 ENST00000623280	A0A024R7W5 [Direct mapping] YTH domain family, member 3, isoform CRA_a; YTH domain-containing family protein 3 Show all	Predicted intracellular proteins Show all		534 aa 58.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.