Expression of KCNQ5 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated KQT-like subfamily Q, member 5

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA016655

GENE INFORMATION
Gene name	KCNQ5 (HGNC Symbol)
Synonyms	Kv7.5
Description	Potassium channel, voltage gated KQT-like subfamily Q, member 5 (HGNC Symbol)
Entrez gene summary	This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	6
Cytoband	q13
Chromosome location (bp)	72621792 - 73198851
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185760 (version 83.38)
Entrez gene	56479
UniProt	Q9NR82 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR82
Antibodypedia	KCNQ5 antibodies

PROTEIN BROWSER

KCNQ5-001	KCNQ5-002	KCNQ5-003	KCNQ5-004	KCNQ5-005	KCNQ5-006	KCNQ5-007	KCNQ5-008	KCNQ5-201	KCNQ5-202	KCNQ5-203	KCNQ5-204	KCNQ5-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNQ5-001 ENSP00000359425 ENST00000370398	Q9NR82 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005242 [inward rectifier potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	932 aa 102.2 kDa	No	5
KCNQ5-002 ENSP00000359419 ENST00000370392	Q9NR82 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005242 [inward rectifier potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	427 aa 46.9 kDa	No	5
KCNQ5-003 ENSP00000391971 ENST00000441538	A6PVT8 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	90 aa 10.5 kDa	No	0
KCNQ5-004 ENSP00000388098 ENST00000427928	H0Y3Z0 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Predicted intracellular proteins Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	97 aa 10.8 kDa	No	0
KCNQ5-005 ENSP00000414829 ENST00000443915	A6PVT7 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	68 aa 8.2 kDa	No	1
KCNQ5-006 ENSP00000345055 ENST00000342056	Q9NR82 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005242 [inward rectifier potassium channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	951 aa 104.5 kDa	No	5
KCNQ5-007 ENSP00000486187 ENST00000628967	Q9NR82 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005242 [inward rectifier potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	822 aa 90 kDa	No	5
KCNQ5-008 ENSP00000485743 ENST00000629977	Q9NR82 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005242 [inward rectifier potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	923 aa 101.3 kDa	No	5
KCNQ5-201 ENSP00000347326 ENST00000355194	F8WEA4 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	932 aa 102.2 kDa	No	5
KCNQ5-202 ENSP00000347853 ENST00000355635	A0A0A0MRC8 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	951 aa 104.5 kDa	No	6
KCNQ5-203 ENSP00000385501 ENST00000402622	A0A0A0MSD9 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	942 aa 103.6 kDa	No	6
KCNQ5-204 ENSP00000384453 ENST00000403813	A0A0A0MSC0 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	923 aa 101.2 kDa	No	6
KCNQ5-205 ENSP00000409861 ENST00000414165	A0A0A0MT07 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	822 aa 90 kDa	No	5