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IKZF1

GENERAL INFORMATION

Gene name

 IKZF1

Gene description

 IKAROS family zinc finger 1 (Ikaros)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

 Intracellular,Membrane

Number of transcripts

 13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Group enriched (spleen, small intestine, lung)
FANTOM5:Tissue enhanced (lymph node, appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression of immune cells in most tissues, most abundant in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA035221 , HPA035222 , CAB009247
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, appendix, tonsil)

GENE INFORMATION

Gene name

 IKZF1 (HGNC Symbol)

Synonyms

 hIk-1, Hs.54452, IKAROS, LyF-1, PPP1R92, ZNFN1A1

Description

 IKAROS family zinc finger 1 (Ikaros) (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

Chromosome

 7

Cytoband

 p12.2

Chromosome location (bp)

 50304124 - 50405101

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185811 (version 83.38)

Entrez gene

 10320

UniProt

 Q13422 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13422

Antibodypedia

 IKZF1 antibodies

PROTEIN BROWSER
«
IKZF1-001
IKZF1-002
IKZF1-003
IKZF1-004
IKZF1-006
IKZF1-007
IKZF1-201
IKZF1-202
IKZF1-203
IKZF1-204
IKZF1-205
IKZF1-206
IKZF1-207
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IKZF1-001
ENSP00000331614
ENST00000331340
Q13422 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001779 [natural killer cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005721 [pericentric heterochromatin]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0007498 [mesoderm development]
GO:0008187 [poly-pyrimidine tract binding]
GO:0010628 [positive regulation of gene expression]
GO:0016568 [chromatin modification]
GO:0030097 [hemopoiesis]
GO:0030098 [lymphocyte differentiation]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030900 [forebrain development]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0032993 [protein-DNA complex]
GO:0035881 [amacrine cell differentiation]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045184 [establishment of protein localization]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045660 [positive regulation of neutrophil differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048535 [lymph node development]
GO:0048538 [thymus development]
GO:0048541 [Peyer's patch development]
GO:0048732 [gland development]
GO:0051138 [positive regulation of NK T cell differentiation]
GO:0060040 [retinal bipolar neuron differentiation]
GO:0060041 [retina development in camera-type eye]
Show all
 519 aa
57.5 kDa 		No 0
IKZF1-002
ENSP00000352123
ENST00000359197
Q13422 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0007498 [mesoderm development]
GO:0016568 [chromatin modification]
GO:0030098 [lymphocyte differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0043234 [protein complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 477 aa
52.7 kDa 		No 0
IKZF1-003
ENSP00000396554
ENST00000438033
Q13422 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0007498 [mesoderm development]
GO:0016568 [chromatin modification]
GO:0030098 [lymphocyte differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0043234 [protein complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 432 aa
48.3 kDa 		No 0
IKZF1-004
ENSP00000413025
ENST00000439701
Q13422 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0007498 [mesoderm development]
GO:0016568 [chromatin modification]
GO:0030098 [lymphocyte differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0043234 [protein complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 477 aa
52.7 kDa 		No 0
IKZF1-006
ENSP00000409588
ENST00000426121
Q3T907 [Direct mapping]
DNA-binding protein Ikaros; Zinc finger protein, subfamily 1A, 1 (Ikaros)
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 67 aa
7.2 kDa 		No 0
IKZF1-007
ENSP00000388478
ENST00000413698
C9JTB0 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 174 aa
19.6 kDa 		No 2
IKZF1-201
ENSP00000342750
ENST00000343574
Q13422 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0007498 [mesoderm development]
GO:0016568 [chromatin modification]
GO:0030098 [lymphocyte differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0043234 [protein complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 432 aa
48.3 kDa 		No 0
IKZF1-202
ENSP00000340080
ENST00000346667
A0A0A0MRA0 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 249 aa
27.8 kDa 		No 0
IKZF1-203
ENSP00000342485
ENST00000349824
Q13422 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0007498 [mesoderm development]
GO:0016568 [chromatin modification]
GO:0030098 [lymphocyte differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0043234 [protein complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 376 aa
41.2 kDa 		No 0
IKZF1-204
ENSP00000349928
ENST00000357364
Q13422 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0007498 [mesoderm development]
GO:0016568 [chromatin modification]
GO:0030098 [lymphocyte differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0043234 [protein complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 432 aa
47.6 kDa 		No 0
IKZF1-205
ENSP00000401507
ENST00000440768
A0A0A0MST1 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 294 aa
32.9 kDa 		No 0
IKZF1-206
ENSP00000483016
ENST00000612658
R9R4D9 [Direct mapping]
DNA-binding protein Ikaros; IKAROS family zinc finger 1 isoform 14
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 268 aa
30 kDa 		No 0
IKZF1-207
ENSP00000478368
ENST00000615491
A0A087WU46 [Direct mapping]
DNA-binding protein Ikaros
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 336 aa
37.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.