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Several breast and prostate cancers along with a few gastric and pancreatic cancers displayed strong cytoplasmic and membranous positivity. Colorectal, liver, urothelial, ovarian and cervical cancers exhibited moderate cytoplasmic staining and additional membranous staining in some cases. Remaining tumor tissues were weakly stained or negative.
Several cases of colorectal cancers along with occasional cases of gastric cancers exhibited strong cytoplasmic positivity in a subset of tumor cells. Rest of the tumors were negative.
GENE INFORMATION
Gene name
NPAP1 (HGNC Symbol)
Synonyms
C15orf2
Description
Nuclear pore associated protein 1 (HGNC Symbol)
Entrez gene summary
This gene is located in the Prader-Willi syndrome region on chromosome 15. This gene is biallelically expressed in adult testis and brain but is paternally imprinted in fetal brain. Defects in this gene may be associated with Prader-Willi syndrome. [provided by RefSeq, Aug 2012]
