Fields »
ABOUT
HELP
BLOG
TRIM69

GENERAL INFORMATION

Gene name

 TRIM69

Gene description

 Tripartite motif containing 69

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA028894
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRIM69 (HGNC Symbol)

Synonyms

 RNF36, Trif, TRIMLESS

Description

 Tripartite motif containing 69 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 44728988 - 44767829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185880 (version 83.38)

Entrez gene

 140691

UniProt

 Q86WT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86WT6

Antibodypedia

 TRIM69 antibodies

PROTEIN BROWSER
TRIM69-001
TRIM69-002
TRIM69-003
TRIM69-004
TRIM69-010
TRIM69-011
TRIM69-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM69-001
ENSP00000342922
ENST00000338264
Q86WT6 [Direct mapping]
E3 ubiquitin-protein ligase TRIM69
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
Show all
 341 aa
39.3 kDa 		No 0
TRIM69-002
ENSP00000453177
ENST00000559390
Q86WT6 [Direct mapping]
E3 ubiquitin-protein ligase TRIM69
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
Show all
 500 aa
57.4 kDa 		No 0
TRIM69-003
ENSP00000453549
ENST00000560442
Q86WT6 [Direct mapping]
E3 ubiquitin-protein ligase TRIM69
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
Show all
 296 aa
34 kDa 		No 0
TRIM69-004
ENSP00000453332
ENST00000558329
Q86WT6 [Direct mapping]
E3 ubiquitin-protein ligase TRIM69
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
Show all
 279 aa
32.1 kDa 		No 0
TRIM69-010
ENSP00000453077
ENST00000561043
H0YL66 [Direct mapping]
E3 ubiquitin-protein ligase TRIM69
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 263 aa
30 kDa 		No 0
TRIM69-011
ENSP00000452739
ENST00000561170
H0YKB8 [Direct mapping]
E3 ubiquitin-protein ligase TRIM69
Show all
Predicted intracellular proteins
Show all
 130 aa
14.8 kDa 		No 0
TRIM69-201
ENSP00000332284
ENST00000329464
Q86WT6 [Direct mapping]
E3 ubiquitin-protein ligase TRIM69
Show all
Predicted intracellular proteins
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
Show all
 500 aa
57.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.