Expression of CALHM1 in cancer - Summary

CANCER ATLAS

Gene description

Calcium homeostasis modulator 1

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018317

GENE INFORMATION
Gene name	CALHM1 (HGNC Symbol)
Synonyms	FAM26C
Description	Calcium homeostasis modulator 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]
Chromosome	10
Cytoband	q24.33
Chromosome location (bp)	103453387 - 103458888
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185933 (version 83.38)
Entrez gene	255022
UniProt	Q8IU99 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IU99
Antibodypedia	CALHM1 antibodies

PROTEIN BROWSER

CALHM1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALHM1-001 ENSP00000329926 ENST00000329905	Q8IU99 [Direct mapping] Calcium homeostasis modulator protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0015867 [ATP transport] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0042802 [identical protein binding] GO:0050909 [sensory perception of taste] GO:0050913 [sensory perception of bitter taste] GO:0050916 [sensory perception of sweet taste] GO:0050917 [sensory perception of umami taste] GO:0051260 [protein homooligomerization] GO:0070588 [calcium ion transmembrane transport] Show all	346 aa 38.3 kDa	No	4