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GRK1

GENERAL INFORMATION

Gene name

 GRK1

Gene description

 G protein-coupled receptor kinase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enriched (thyroid gland)
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in photoreceptor cells.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 2 antibodies.
HPA035200 , HPA059376
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 GRK1 (HGNC Symbol)

Synonyms

 GPRK1, RHOK, RK

Description

 G protein-coupled receptor kinase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q34

Chromosome location (bp)

 113667155 - 113737735

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185974 (version 83.38)

Entrez gene

UniProt

 Q15835 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15835

Antibodypedia

 GRK1 antibodies

PROTEIN BROWSER
GRK1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRK1-001
ENSP00000334876
ENST00000335678
Q15835 [Direct mapping]
Rhodopsin kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
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GO:0001750 [photoreceptor outer segment]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004703 [G-protein coupled receptor kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0008594 [photoreceptor cell morphogenesis]
GO:0009416 [response to light stimulus]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0043066 [negative regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0050254 [rhodopsin kinase activity]
GO:0060060 [post-embryonic retina morphogenesis in camera-type eye]
GO:0097381 [photoreceptor disc membrane]
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 563 aa
63.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.