Expression of LRCH3 in cancer - Summary

CANCER ATLAS

Gene description

Leucine-rich repeats and calponin homology (CH) domain containing 3

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012380

GENE INFORMATION
Gene name	LRCH3 (HGNC Symbol)
Synonyms	MGC4126
Description	Leucine-rich repeats and calponin homology (CH) domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q29
Chromosome location (bp)	197791226 - 197888436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186001 (version 83.38)
Entrez gene	84859
UniProt	Q96II8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96II8
Antibodypedia	LRCH3 antibodies

PROTEIN BROWSER

LRCH3-001	LRCH3-002	LRCH3-003	LRCH3-004	LRCH3-006	LRCH3-009	LRCH3-015	LRCH3-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRCH3-001 ENSP00000399751 ENST00000438796	Q96II8 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] Show all	803 aa 89.1 kDa	Yes	1
LRCH3-002 ENSP00000394609 ENST00000441090	E9PD99 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	623 aa 68.5 kDa	Yes	0
LRCH3-003 ENSP00000394965 ENST00000414675	Q96II8 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] Show all	725 aa 80.4 kDa	Yes	0
LRCH3-004 ENSP00000334375 ENST00000334859	Q96II8 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] Show all	712 aa 78.8 kDa	Yes	0
LRCH3-006 ENSP00000393579 ENST00000425562	Q96II8 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] Show all	777 aa 86.1 kDa	Yes	0
LRCH3-009 ENSP00000394763 ENST00000428136	H7C0F9 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	181 aa 19.9 kDa	No	1
LRCH3-015 ENSP00000395309 ENST00000452660	H7C0J8 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	227 aa 24.8 kDa	No	0
LRCH3-017 ENSP00000400164 ENST00000433298	H7C1G3 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	214 aa 23.3 kDa	No	0