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HTR3E

CANCER ATLAS

Gene description

 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic

Protein class

 Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049764

GENE INFORMATION

Gene name

 HTR3E

Synonyms

Description

 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic (HGNC Symbol)

Entrez gene summary

 This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]

Chromosome

 3

Cytoband

 q27.1

Chromosome location (bp)

 184097064 - 184106995

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186038 (version 83.38)

Entrez gene

 285242

UniProt

 A5X5Y0 (UniProt - Evidence at protein level)

neXtProt

 NX_A5X5Y0

Antibodypedia

 HTR3E antibodies

PROTEIN BROWSER
HTR3E-001
HTR3E-002
HTR3E-003
HTR3E-004
HTR3E-006
HTR3E-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR3E-001
ENSP00000335511
ENST00000335304
A5X5Y0 [Direct mapping]
5-hydroxytryptamine receptor 3E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0004993 [serotonin receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005232 [serotonin-activated cation-selective channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007210 [serotonin receptor signaling pathway]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 471 aa
52.8 kDa 		No 4
HTR3E-002
ENSP00000401900
ENST00000425359
A5X5Y0 [Direct mapping]
5-hydroxytryptamine receptor 3E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0004993 [serotonin receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005232 [serotonin-activated cation-selective channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007210 [serotonin receptor signaling pathway]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 441 aa
49.6 kDa 		Yes 4
HTR3E-003
ENSP00000401444
ENST00000415389
A5X5Y0 [Direct mapping]
5-hydroxytryptamine receptor 3E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0004993 [serotonin receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005232 [serotonin-activated cation-selective channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007210 [serotonin receptor signaling pathway]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 456 aa
51.4 kDa 		Yes 4
HTR3E-004
ENSP00000395833
ENST00000436361
A5X5Y0 [Direct mapping]
5-hydroxytryptamine receptor 3E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0004993 [serotonin receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005232 [serotonin-activated cation-selective channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007210 [serotonin receptor signaling pathway]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 456 aa
51 kDa 		No 4
HTR3E-006
ENSP00000391254
ENST00000431041
C9J420 [Direct mapping]
5-hydroxytryptamine receptor 3E
Show all
Predicted intracellular proteins
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 158 aa
18.4 kDa 		No 0
HTR3E-007
ENSP00000406050
ENST00000440596
A5X5Y0 [Direct mapping]
5-hydroxytryptamine receptor 3E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004889 [acetylcholine-activated cation-selective channel activity]
GO:0004993 [serotonin receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005232 [serotonin-activated cation-selective channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007210 [serotonin receptor signaling pathway]
GO:0015464 [acetylcholine receptor activity]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0042166 [acetylcholine binding]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 482 aa
53.7 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.