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PIP5K1C

CANCER ATLAS

Gene description

 Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017168

GENE INFORMATION

Gene name

 PIP5K1C (HGNC Symbol)

Synonyms

 KIAA0589, LCCS3, PIP5Kgamma

Description

 Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (HGNC Symbol)

Entrez gene summary

 This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 3630183 - 3700479

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186111 (version 83.38)

Entrez gene

 23396

UniProt

 O60331 (UniProt - Evidence at protein level)

neXtProt

 NX_O60331

Antibodypedia

 PIP5K1C antibodies

PROTEIN BROWSER
PIP5K1C-001
PIP5K1C-002
PIP5K1C-003
PIP5K1C-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIP5K1C-001
ENSP00000335333
ENST00000335312
O60331 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0001931 [uropod]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006909 [phagocytosis]
GO:0007411 [axon guidance]
GO:0012505 [endomembrane system]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030593 [neutrophil chemotaxis]
GO:0032587 [ruffle membrane]
GO:0034333 [adherens junction assembly]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048488 [synaptic vesicle endocytosis]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 668 aa
73.3 kDa 		No 0
PIP5K1C-002
ENSP00000445992
ENST00000539785
O60331 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0001931 [uropod]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006909 [phagocytosis]
GO:0007411 [axon guidance]
GO:0012505 [endomembrane system]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030593 [neutrophil chemotaxis]
GO:0032587 [ruffle membrane]
GO:0034333 [adherens junction assembly]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048488 [synaptic vesicle endocytosis]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 640 aa
70.2 kDa 		No 0
PIP5K1C-003
ENSP00000466363
ENST00000589578
O60331 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0001931 [uropod]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005623 [cell]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006909 [phagocytosis]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0012505 [endomembrane system]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030593 [neutrophil chemotaxis]
GO:0032587 [ruffle membrane]
GO:0034333 [adherens junction assembly]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048488 [synaptic vesicle endocytosis]
GO:0070527 [platelet aggregation]
GO:0072583 [clathrin-mediated endocytosis]
GO:1990147 [talin binding]
Show all
 707 aa
77.5 kDa 		No 0
PIP5K1C-005
ENSP00000444779
ENST00000537021
O60331 [Direct mapping]
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0001931 [uropod]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006909 [phagocytosis]
GO:0007411 [axon guidance]
GO:0012505 [endomembrane system]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016308 [1-phosphatidylinositol-4-phosphate 5-kinase activity]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030593 [neutrophil chemotaxis]
GO:0032587 [ruffle membrane]
GO:0034333 [adherens junction assembly]
GO:0044281 [small molecule metabolic process]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048488 [synaptic vesicle endocytosis]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 700 aa
76.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.