Cell atlas - CYP4F2 - The Human Protein Atlas

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CYP4F2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CYP4F2
Gene description	Cytochrome P450, family 4, subfamily F, polypeptide 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (Hep G2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CYP4F2
Synonyms
Description	Cytochrome P450, family 4, subfamily F, polypeptide 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	15878023 - 15898120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186115 (version 83.38)
Entrez gene	8529
UniProt	P78329 (UniProt - Evidence at protein level)
neXtProt	NX_P78329
Antibodypedia	CYP4F2 antibodies

PROTEIN BROWSER

CYP4F2-001	CYP4F2-005	CYP4F2-007	CYP4F2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP4F2-001 ENSP00000221700 ENST00000221700	P78329 [Direct mapping] Phylloquinone omega-hydroxylase CYP4F2 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000038 [very long-chain fatty acid metabolic process] GO:0001676 [long-chain fatty acid metabolic process] GO:0003091 [renal water homeostasis] GO:0003095 [pressure natriuresis] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006690 [icosanoid metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007596 [blood coagulation] GO:0008217 [regulation of blood pressure] GO:0008392 [arachidonic acid epoxygenase activity] GO:0016324 [apical plasma membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0017144 [drug metabolic process] GO:0018685 [alkane 1-monooxygenase activity] GO:0019369 [arachidonic acid metabolic process] GO:0019373 [epoxygenase P450 pathway] GO:0020037 [heme binding] GO:0032304 [negative regulation of icosanoid secretion] GO:0032305 [positive regulation of icosanoid secretion] GO:0036101 [leukotriene B4 catabolic process] GO:0042360 [vitamin E metabolic process] GO:0042361 [menaquinone catabolic process] GO:0042376 [phylloquinone catabolic process] GO:0042377 [vitamin K catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0050051 [leukotriene-B4 20-monooxygenase activity] GO:0052869 [arachidonic acid omega-hydroxylase activity] GO:0052871 [alpha-tocopherol omega-hydroxylase activity] GO:0052872 [tocotrienol omega-hydroxylase activity] GO:0055078 [sodium ion homeostasis] GO:0055114 [oxidation-reduction process] GO:0097267 [omega-hydroxylase P450 pathway] Show all	520 aa 59.9 kDa	Yes	0
CYP4F2-005 ENSP00000465514 ENST00000586927	K7EK90 [Direct mapping] Phylloquinone omega-hydroxylase CYP4F2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	154 aa 17.6 kDa	No	1
CYP4F2-007 ENSP00000467846 ENST00000589654	K7EQI8 [Direct mapping] Phylloquinone omega-hydroxylase CYP4F2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	74 aa 8.9 kDa	No	0
CYP4F2-201 ENSP00000011989 ENST00000011989	A0A0A0MQR0 [Direct mapping] Cytochrome P450, family 4, subfamily F, polypeptide 2, isoform CRA_a; Phylloquinone omega-hydroxylase CYP4F2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	520 aa 59.9 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.