Expression of BTLA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

B and T lymphocyte associated

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Urothelial cancer

STAINING SUMMARY

HPA047211	HPA062029

GENE INFORMATION
Gene name	BTLA (HGNC Symbol)
Synonyms	BTLA1, CD272
Description	B and T lymphocyte associated (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
Chromosome	3
Cytoband	q13.2
Chromosome location (bp)	112463968 - 112499561
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186265 (version 83.38)
Entrez gene	151888
UniProt	Q7Z6A9 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z6A9
Antibodypedia	BTLA antibodies

PROTEIN BROWSER

BTLA-001	BTLA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTLA-001 ENSP00000333919 ENST00000334529	Q7Z6A9 [Direct mapping] B- and T-lymphocyte attenuator Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002768 [immune response-regulating cell surface receptor signaling pathway] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0030889 [negative regulation of B cell proliferation] GO:0031295 [T cell costimulation] GO:0042130 [negative regulation of T cell proliferation] GO:0046642 [negative regulation of alpha-beta T cell proliferation] Show all	289 aa 32.8 kDa	No	1
BTLA-002 ENSP00000373178 ENST00000383680	Q7Z6A9 [Direct mapping] B- and T-lymphocyte attenuator Show all	CD markers THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0031295 [T cell costimulation] Show all	241 aa 27.3 kDa	No	0