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Several liver cancers showed strong granular/dot like cytoplasmic staining. Several cases of duct carcinomas of breast, squamous cell carcinomas of cervix, adenocarcinomas of lung, ovarian, renal cancers along with few cases of endometrial and urothelial cancers displayed moderate to strong positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
OR10X1 (HGNC Symbol)
Synonyms
OR10X1P
Description
Olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene) (HGNC Symbol)
Entrez gene summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
