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GNG2

GENERAL INFORMATION

Gene name

 GNG2

Gene description

 Guanine nucleotide binding protein (G protein), gamma 2

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Tissue enriched (testis)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous membranous and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA003534 , CAB018380
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Appendix
N/A
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GNG2

Synonyms

Description

 Guanine nucleotide binding protein (G protein), gamma 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]

Chromosome

 14

Cytoband

 q22.1

Chromosome location (bp)

 51826195 - 51979342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186469 (version 83.38)

Entrez gene

 54331

UniProt

 P59768 (UniProt - Evidence at protein level)

neXtProt

 NX_P59768

Antibodypedia

 GNG2 antibodies

PROTEIN BROWSER
GNG2-001
GNG2-002
GNG2-005
GNG2-006
GNG2-009
GNG2-010
GNG2-012
GNG2-014
GNG2-016
GNG2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNG2-001
ENSP00000451576
ENST00000556752
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-002
ENSP00000334448
ENST00000335281
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-005
ENSP00000451231
ENST00000556766
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-006
ENSP00000450586
ENST00000553560
G3V2C9 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 52 aa
5.9 kDa 		No 0
GNG2-009
ENSP00000452014
ENST00000554736
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-010
ENSP00000451102
ENST00000555472
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0
GNG2-012
ENSP00000451536
ENST00000554875
G3V415 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 61 aa
6.9 kDa 		No 0
GNG2-014
ENSP00000451279
ENST00000553432
G3V3J9 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 102 aa
11.2 kDa 		No 0
GNG2-016
ENSP00000450758
ENST00000557376
G3V2N0 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 110 aa
12.4 kDa 		No 0
GNG2-201
ENSP00000484021
ENST00000615906
P59768 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
Show all
 71 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.