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PCLO

CANCER ATLAS

Gene description

 Piccolo presynaptic cytomatrix protein

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA015858
HPA029579

GENE INFORMATION

Gene name

 PCLO (HGNC Symbol)

Synonyms

 ACZ, DKFZp779G1236, KIAA0559

Description

 Piccolo presynaptic cytomatrix protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 7

Cytoband

 q21.11

Chromosome location (bp)

 82754013 - 83162930

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186472 (version 83.38)

Entrez gene

 27445

UniProt

 Q9Y6V0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6V0

Antibodypedia

 PCLO antibodies

PROTEIN BROWSER
PCLO-001
PCLO-003
PCLO-011
PCLO-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PCLO-001
ENSP00000334319
ENST00000333891
Q9Y6V0 [Direct mapping]
Protein piccolo
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005622 [intracellular]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007416 [synapse assembly]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019933 [cAMP-mediated signaling]
GO:0030054 [cell junction]
GO:0030073 [insulin secretion]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0048788 [cytoskeleton of presynaptic active zone]
GO:0070062 [extracellular exosome]
Show all
 5142 aa
560.7 kDa 		No 0
PCLO-003
ENSP00000393760
ENST00000437081
E9PE96 [Direct mapping]
Protein piccolo
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007416 [synapse assembly]
GO:0016021 [integral component of membrane]
GO:0048786 [presynaptic active zone]
Show all
 1217 aa
136.4 kDa 		No 1
PCLO-011
ENSP00000388393
ENST00000423517
Q9Y6V0 [Direct mapping]
Protein piccolo
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007416 [synapse assembly]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0030054 [cell junction]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0048788 [cytoskeleton of presynaptic active zone]
GO:0070062 [extracellular exosome]
Show all
 4935 aa
537.9 kDa 		No 0
PCLO-201
ENSP00000482390
ENST00000618073
Q9Y6V0 [Direct mapping]
Protein piccolo
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007416 [synapse assembly]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0030054 [cell junction]
GO:0045202 [synapse]
GO:0048788 [cytoskeleton of presynaptic active zone]
GO:0070062 [extracellular exosome]
Show all
 356 aa
39 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.