Expression of RGS7BP in cancer - Summary

CANCER ATLAS

Gene description

Regulator of G-protein signaling 7 binding protein

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039600

GENE INFORMATION
Gene name	RGS7BP (HGNC Symbol)
Synonyms	R7BP
Description	Regulator of G-protein signaling 7 binding protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Chromosome	5
Cytoband	q12.3
Chromosome location (bp)	64506257 - 64612312
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186479 (version 83.38)
Entrez gene	401190
UniProt	Q6MZT1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6MZT1
Antibodypedia	RGS7BP antibodies

PROTEIN BROWSER

RGS7BP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RGS7BP-001 ENSP00000334851 ENST00000334025	Q6MZT1 [Direct mapping] Regulator of G-protein signaling 7-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009968 [negative regulation of signal transduction] Show all	257 aa 29 kDa	No	0