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A few cases of malignant lymphomas, testicular and urothelial cancers exhibited weak to moderate nuclear positivity. A fraction of malignant cells in rare cases of prostate cancers showed strong cytoplasmic staining. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
DEFB107A (HGNC Symbol)
Synonyms
DEFB-7, DEFB107
Description
Defensin, beta 107A (HGNC Symbol)
Entrez gene summary
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
