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A few cases of squamous cell carcinomas of cervix showed moderate cytoplasmic positivity in a fraction of tumor cells. Peripheral nerves in the stroma were stained. Remaining cancers were mainly negative.
GENE INFORMATION
Gene name
DEFB106A (HGNC Symbol)
Synonyms
DEFB-6, DEFB106
Description
Defensin, beta 106A (HGNC Symbol)
Entrez gene summary
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]