Cell atlas - HPDL - The Human Protein Atlas

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HPDL

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	HPDL
Gene description	4-hydroxyphenylpyruvate dioxygenase-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria.
RNA cell category	Cell line enhanced (BEWO, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA031997 , HPA057346
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031997	CACO-2	Mitochondria
	HPA031997	MCF7	Mitochondria
	HPA057346	CACO-2	Nucleoplasm	Intensity
	HPA057346	CACO-2	Mitochondria	Intensity
	HPA057346	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	HPDL (HGNC Symbol)
Synonyms	4-HPPD-L, GLOXD1, MGC15668
Description	4-hydroxyphenylpyruvate dioxygenase-like (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.1
Chromosome location (bp)	45326905 - 45328533
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186603 (version 83.38)
Entrez gene	84842
UniProt	Q96IR7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96IR7
Antibodypedia	HPDL antibodies

PROTEIN BROWSER

HPDL-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HPDL-001 ENSP00000335060 ENST00000334815	Q96IR7 [Direct mapping] 4-hydroxyphenylpyruvate dioxygenase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003868 [4-hydroxyphenylpyruvate dioxygenase activity] GO:0009072 [aromatic amino acid family metabolic process] GO:0016701 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	371 aa 39.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.