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KATNA1

CANCER ATLAS

Gene description

 Katanin p60 (ATPase containing) subunit A 1

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA036207

GENE INFORMATION

Gene name

 KATNA1

Synonyms

Description

 Katanin p60 (ATPase containing) subunit A 1 (HGNC Symbol)

Entrez gene summary

 Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

Chromosome

 6

Cytoband

 q25.1

Chromosome location (bp)

 149594873 - 149648972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186625 (version 83.38)

Entrez gene

 11104

UniProt

 O75449 (UniProt - Evidence at protein level)

neXtProt

 NX_O75449

Antibodypedia

 KATNA1 antibodies

PROTEIN BROWSER
KATNA1-001
KATNA1-002
KATNA1-004
KATNA1-005
KATNA1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KATNA1-001
ENSP00000335106
ENST00000335647
O75449 [Direct mapping]
Katanin p60 ATPase-containing subunit A1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0007067 [mitotic nuclear division]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008568 [microtubule-severing ATPase activity]
GO:0030496 [midbody]
GO:0031122 [cytoplasmic microtubule organization]
GO:0046982 [protein heterodimerization activity]
GO:0051013 [microtubule severing]
GO:0051301 [cell division]
Show all
 491 aa
56 kDa 		No 0
KATNA1-002
ENSP00000335180
ENST00000335643
O75449 [Direct mapping]
Katanin p60 ATPase-containing subunit A1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0007067 [mitotic nuclear division]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008568 [microtubule-severing ATPase activity]
GO:0030496 [midbody]
GO:0031122 [cytoplasmic microtubule organization]
GO:0046982 [protein heterodimerization activity]
GO:0051013 [microtubule severing]
GO:0051301 [cell division]
Show all
 311 aa
35.3 kDa 		No 0
KATNA1-004
ENSP00000390322
ENST00000444282
B7ZBC8 [Direct mapping]
Katanin p60 ATPase-containing subunit A1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005815 [microtubule organizing center]
GO:0031122 [cytoplasmic microtubule organization]
Show all
 280 aa
31.8 kDa 		No 0
KATNA1-005
ENSP00000398993
ENST00000420200
B7ZBC9 [Direct mapping]
Katanin p60 ATPase-containing subunit A1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005815 [microtubule organizing center]
GO:0031122 [cytoplasmic microtubule organization]
Show all
 211 aa
24.3 kDa 		No 0
KATNA1-201
ENSP00000356381
ENST00000367411
O75449 [Direct mapping]
Katanin p60 ATPase-containing subunit A1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007067 [mitotic nuclear division]
GO:0008017 [microtubule binding]
GO:0008104 [protein localization]
GO:0008152 [metabolic process]
GO:0008568 [microtubule-severing ATPase activity]
GO:0010977 [negative regulation of neuron projection development]
GO:0016887 [ATPase activity]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0031122 [cytoplasmic microtubule organization]
GO:0043025 [neuronal cell body]
GO:0045502 [dynein binding]
GO:0046982 [protein heterodimerization activity]
GO:0051013 [microtubule severing]
GO:0051301 [cell division]
Show all
 491 aa
56 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.