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Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
P13727 [Direct mapping] Bone marrow proteoglycan Eosinophil granule major basic protein
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002215 [defense response to nematode] GO:0005576 [extracellular region] GO:0006955 [immune response] GO:0008201 [heparin binding] GO:0030133 [transport vesicle] GO:0030246 [carbohydrate binding] GO:0032693 [negative regulation of interleukin-10 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0042035 [regulation of cytokine biosynthetic process] GO:0042742 [defense response to bacterium] GO:0070062 [extracellular exosome]
P13727 [Direct mapping] Bone marrow proteoglycan Eosinophil granule major basic protein
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
