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Most of the cancer cells displayed moderate nucleolar/nuclear positivity witch in many cell types was combined with additional cytoplasmic staining. Testicular cancers were generally weakly stained or negative.
Strong nuclear positivity was observed in most cancer tissues.
GENE INFORMATION
Gene name
ZFP91 (HGNC Symbol)
Synonyms
PZF, ZNF757
Description
ZFP91 zinc finger protein (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
