Tissue expression of FSCN2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FSCN2
Gene description	Fascin actin-bundling protein 2, retinal
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (parathyroid gland, thyroid gland)
GTEx:	Tissue enhanced (thyroid gland)
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (parathyroid gland, thyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	FSCN2 (HGNC Symbol)
Synonyms	RFSN, RP30
Description	Fascin actin-bundling protein 2, retinal (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81528396 - 81537130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186765 (version 83.38)
Entrez gene	25794
UniProt	O14926 (UniProt - Evidence at protein level)
neXtProt	NX_O14926
Antibodypedia	FSCN2 antibodies

PROTEIN BROWSER

FSCN2-001	FSCN2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FSCN2-001 ENSP00000388716 ENST00000417245	O14926 [Direct mapping] Fascin-2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0007601 [visual perception] GO:0009653 [anatomical structure morphogenesis] GO:0015629 [actin cytoskeleton] GO:0030036 [actin cytoskeleton organization] GO:0030674 [protein binding, bridging] GO:0032420 [stereocilium] GO:0051015 [actin filament binding] GO:0051017 [actin filament bundle assembly] Show all	492 aa 55.1 kDa	No	0
FSCN2-003 ENSP00000334665 ENST00000334850	O14926 [Direct mapping] Fascin-2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0007601 [visual perception] GO:0009653 [anatomical structure morphogenesis] GO:0015629 [actin cytoskeleton] GO:0030036 [actin cytoskeleton organization] GO:0030674 [protein binding, bridging] GO:0032403 [protein complex binding] GO:0032420 [stereocilium] GO:0042462 [eye photoreceptor cell development] GO:0051015 [actin filament binding] GO:0051017 [actin filament bundle assembly] Show all	516 aa 57.4 kDa	No	0