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CXCR3

GENERAL INFORMATION

Gene name

 CXCR3

Gene description

 Chemokine (C-X-C motif) receptor 3

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Group enriched (spleen, small intestine)
FANTOM5:Tissue enhanced (tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in a subset of leukocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA045942
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil)

GENE INFORMATION

Gene name

 CXCR3 (HGNC Symbol)

Synonyms

 CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR

Description

 Chemokine (C-X-C motif) receptor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 71615916 - 71618517

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186810 (version 83.38)

Entrez gene

 2833

UniProt

 P49682 (UniProt - Evidence at protein level)

neXtProt

 NX_P49682

Antibodypedia

 CXCR3 antibodies

PROTEIN BROWSER
CXCR3-001
CXCR3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCR3-001
ENSP00000362795
ENST00000373691
P49682 [Direct mapping]
C-X-C chemokine receptor type 3
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002685 [regulation of leukocyte migration]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010818 [T cell chemotaxis]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0019722 [calcium-mediated signaling]
GO:0019956 [chemokine binding]
GO:0019958 [C-X-C chemokine binding]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050921 [positive regulation of chemotaxis]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0071954 [chemokine (C-C motif) ligand 11 production]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 415 aa
45.5 kDa 		No 7
CXCR3-002
ENSP00000362797
ENST00000373693
P49682 [Direct mapping]
C-X-C chemokine receptor type 3
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002685 [regulation of leukocyte migration]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0019956 [chemokine binding]
GO:0019958 [C-X-C chemokine binding]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050921 [positive regulation of chemotaxis]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0071954 [chemokine (C-C motif) ligand 11 production]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 368 aa
40.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.