Expression of ZNF397 in cancer - Summary

CANCER ATLAS

Gene description

Zinc finger protein 397

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026087

GENE INFORMATION
Gene name	ZNF397 (HGNC Symbol)
Synonyms	MGC13250, ZNF47, ZSCAN15
Description	Zinc finger protein 397 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Chromosome	18
Cytoband	q12.2
Chromosome location (bp)	35241030 - 35267133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186812 (version 83.38)
Entrez gene	84307
UniProt	Q8NF99 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NF99
Antibodypedia	ZNF397 antibodies

PROTEIN BROWSER

ZNF397-001	ZNF397-002	ZNF397-004	ZNF397-005	ZNF397-006	ZNF397-008	ZNF397-009	ZNF397-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF397-001 ENSP00000331577 ENST00000330501	Q8NF99 [Direct mapping] Zinc finger protein 397 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	534 aa 61.1 kDa	No	0
ZNF397-002 ENSP00000466317 ENST00000591206	Q8NF99 [Direct mapping] Zinc finger protein 397 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	207 aa 24.1 kDa	No	0
ZNF397-004 ENSP00000347850 ENST00000355632	Q96K65 [Direct mapping] Zinc finger protein 397; Zinc finger protein 397, isoform CRA_b; cDNA FLJ14478 fis, clone MAMMA1001633, moderately similar to ZINC FINGER PROTEIN 165 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	245 aa 27.8 kDa	No	0
ZNF397-005 ENSP00000261333 ENST00000261333	Q8NF99 [Direct mapping] Zinc finger protein 397 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	275 aa 31.1 kDa	No	0
ZNF397-006 ENSP00000466760 ENST00000585800	Q8NF99 [Direct mapping] Zinc finger protein 397 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	207 aa 24.1 kDa	No	0
ZNF397-008 ENSP00000468413 ENST00000592264	K7ERU5 [Direct mapping] Zinc finger protein 397 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	188 aa 21.7 kDa	No	0
ZNF397-009 ENSP00000464808 ENST00000588119	K7EIM5 [Direct mapping] Zinc finger protein 397 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	201 aa 23 kDa	No	0
ZNF397-012 ENSP00000472393 ENST00000601719	M0R288 [Direct mapping] Zinc finger protein 397 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	139 aa 16.3 kDa	No	0