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A fraction of tumor cells in a few melanomas, colorectal and renal cancers displayed moderate cytoplasmic staining. Remaining cancer cells were negative.
GENE INFORMATION
Gene name
LILRB4 (HGNC Symbol)
Synonyms
CD85k, HM18, ILT3, LIR-5, LIR5
Description
Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 (HGNC Symbol)
Entrez gene summary
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
