Cell atlas - ERCC6L - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ERCC6L
Gene description	Excision repair cross-complementation group 6-like
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the centrosome. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (supported)
Additional location	In addition localized to the Nucleoplasm (supported), Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Centrosome in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA050492
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the centrosome. In addition localized to the cytosol & nucleoplasm.

Main location

Centrosome (supported)

Additional location

Nucleoplasm (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA050492	A-431	Nucleoplasm
		Plasma membrane
		Centrosome
		Cytosol
HPA050492	PC-3	Nucleoplasm
		Centrosome
		Cytosol
HPA050492	U-2 OS	Centrosome	Intensity

MOUSE CELLS

Main location

Centrosome

Additional location

Nucleoplasm, Cytosol

Mouse gene

ENSMUSG00000051220 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

GENE INFORMATION
Gene name	ERCC6L (HGNC Symbol)
Synonyms	FLJ20105, PICH, RAD26L
Description	Excision repair cross-complementation group 6-like (HGNC Symbol)
Entrez gene summary
Chromosome	X
Cytoband	q13.1
Chromosome location (bp)	72204657 - 72239047
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186871 (version 83.38)
Entrez gene	54821
UniProt	Q2NKX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q2NKX8
Antibodypedia	ERCC6L antibodies

PROTEIN BROWSER

ERCC6L-001	ERCC6L-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERCC6L-001 ENSP00000362761 ENST00000373657	B5MDQ0 [Direct mapping] DNA excision repair protein ERCC-6-like; FLJ20105 protein, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] Show all	1127 aa 127 kDa	No	0
ERCC6L-002 ENSP00000334675 ENST00000334463	Q2NKX8 [Direct mapping] DNA excision repair protein ERCC-6-like Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000777 [condensed chromosome kinetochore] GO:0003677 [DNA binding] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0051301 [cell division] Show all	1250 aa 141.1 kDa	No	0