Expression of TNFRSF18 in cancer - Summary

CANCER ATLAS

Gene description

Tumor necrosis factor receptor superfamily, member 18

Protein class

CD markers, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008025

GENE INFORMATION
Gene name	TNFRSF18 (HGNC Symbol)
Synonyms	AITR, CD357, GITR
Description	Tumor necrosis factor receptor superfamily, member 18 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1203508 - 1206691
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186891 (version 83.38)
Entrez gene	8784
UniProt	Q9Y5U5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5U5
Antibodypedia	TNFRSF18 antibodies

PROTEIN BROWSER

TNFRSF18-001	TNFRSF18-002	TNFRSF18-003	TNFRSF18-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFRSF18-001 ENSP00000368570 ENST00000379268	Q9Y5U5 [Direct mapping] Tumor necrosis factor receptor superfamily member 18 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002687 [positive regulation of leukocyte migration] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein] GO:0043066 [negative regulation of apoptotic process] GO:0045785 [positive regulation of cell adhesion] Show all	241 aa 26 kDa	Yes	1
TNFRSF18-002 ENSP00000368567 ENST00000379265	Q9Y5U5 [Direct mapping] Tumor necrosis factor receptor superfamily member 18 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002687 [positive regulation of leukocyte migration] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein] GO:0043066 [negative regulation of apoptotic process] GO:0045785 [positive regulation of cell adhesion] Show all	234 aa 25.1 kDa	Yes	1
TNFRSF18-003 ENSP00000328207 ENST00000328596	Q9Y5U5 [Direct mapping] Tumor necrosis factor receptor superfamily member 18 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002687 [positive regulation of leukocyte migration] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0009897 [external side of plasma membrane] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein] GO:0043066 [negative regulation of apoptotic process] GO:0045785 [positive regulation of cell adhesion] Show all	255 aa 26.8 kDa	Yes	0
TNFRSF18-004 ENSP00000462735 ENST00000486728	J3KT02 [Direct mapping] Tumor necrosis factor receptor superfamily member 18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] Show all	169 aa 18.5 kDa	No	1