Expression of P2RY4 in cancer - Summary

CANCER ATLAS

Gene description

Pyrimidinergic receptor P2Y, G-protein coupled, 4

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

CAB022644

GENE INFORMATION
Gene name	P2RY4 (HGNC Symbol)
Synonyms	NRU, P2P, P2Y4, UNR
Description	Pyrimidinergic receptor P2Y, G-protein coupled, 4 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q13.1
Chromosome location (bp)	70258170 - 70259764
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186912 (version 83.38)
Entrez gene	5030
UniProt	P51582 (UniProt - Evidence at protein level)
neXtProt	NX_P51582
Antibodypedia	P2RY4 antibodies

PROTEIN BROWSER

P2RY4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P2RY4-001 ENSP00000363643 ENST00000374519	P51582 [Direct mapping] P2Y purinoceptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0015065 [uridine nucleotide receptor activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0030321 [transepithelial chloride transport] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] GO:0045030 [UTP-activated nucleotide receptor activity] GO:0071380 [cellular response to prostaglandin E stimulus] Show all	365 aa 41 kDa	No	7