Expression of PLCD1 in cancer - Summary

CANCER ATLAS

Gene description

Phospholipase C, delta 1

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA020107	HPA021677	CAB009913

GENE INFORMATION
Gene name	PLCD1
Synonyms
Description	Phospholipase C, delta 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38007496 - 38029762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187091 (version 83.38)
Entrez gene	5333
UniProt	P51178 (UniProt - Evidence at protein level)
neXtProt	NX_P51178
Antibodypedia	PLCD1 antibodies

PROTEIN BROWSER

PLCD1-001	PLCD1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLCD1-001 ENSP00000335600 ENST00000334661	P51178 [Direct mapping] 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0016042 [lipid catabolic process] GO:0032794 [GTPase activating protein binding] GO:0035556 [intracellular signal transduction] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	756 aa 85.7 kDa	No	0
PLCD1-006 ENSP00000430344 ENST00000463876	P51178 [Direct mapping] 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001786 [phosphatidylserine binding] GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004629 [phospholipase C activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0016042 [lipid catabolic process] GO:0032794 [GTPase activating protein binding] GO:0035556 [intracellular signal transduction] GO:0042127 [regulation of cell proliferation] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0060716 [labyrinthine layer blood vessel development] GO:0070062 [extracellular exosome] GO:0070300 [phosphatidic acid binding] GO:1901981 [phosphatidylinositol phosphate binding] Show all	777 aa 88.1 kDa	No	0