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DYNC2H1

CANCER ATLAS

Gene description

 Dynein, cytoplasmic 2, heavy chain 1

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039015
HPA039016

GENE INFORMATION

Gene name

 DYNC2H1 (HGNC Symbol)

Synonyms

 DHC1b, DHC2, DNCH2, DYH1B, hdhc11

Description

 Dynein, cytoplasmic 2, heavy chain 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

Chromosome

 11

Cytoband

 q22.3

Chromosome location (bp)

 103109431 - 103479863

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187240 (version 83.38)

Entrez gene

 79659

UniProt

 Q8NCM8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NCM8

Antibodypedia

 DYNC2H1 antibodies

PROTEIN BROWSER
DYNC2H1-001
DYNC2H1-002
DYNC2H1-005
DYNC2H1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DYNC2H1-001
ENSP00000364887
ENST00000375735
Q8NCM8 [Direct mapping]
Cytoplasmic dynein 2 heavy chain 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0007030 [Golgi organization]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 4307 aa
492.6 kDa 		No 0
DYNC2H1-002
ENSP00000334021
ENST00000334267
Q8NCM8 [Direct mapping]
Cytoplasmic dynein 2 heavy chain 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0007030 [Golgi organization]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 920 aa
105.4 kDa 		No 0
DYNC2H1-005
ENSP00000381167
ENST00000398093
Q8NCM8 [Direct mapping]
Cytoplasmic dynein 2 heavy chain 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005930 [axoneme]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0007030 [Golgi organization]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0008105 [asymmetric protein localization]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016485 [protein processing]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0030182 [neuron differentiation]
GO:0030286 [dynein complex]
GO:0030326 [embryonic limb morphogenesis]
GO:0030900 [forebrain development]
GO:0031512 [motile primary cilium]
GO:0035721 [intraciliary retrograde transport]
GO:0042384 [cilium assembly]
GO:0045177 [apical part of cell]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0060271 [cilium morphogenesis]
GO:0060976 [coronary vasculature development]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 4314 aa
493.4 kDa 		No 0
DYNC2H1-007
ENSP00000436736
ENST00000533197
H0YEX1 [Direct mapping]
Cytoplasmic dynein 2 heavy chain 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0030286 [dynein complex]
Show all
 224 aa
25 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.