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CIDEC

GENERAL INFORMATION

Gene name

 CIDEC

Gene description

 Cell death-inducing DFFA-like effector c

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adipose tissue)
GTEx:Group enriched (adipose tissue, breast)
FANTOM5:Group enriched (adipose tissue, small intestine, colon, breast)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues with extracellular positivity, including adipocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA018837 , HPA020553
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, small intestine, colon, breast)

GENE INFORMATION

Gene name

 CIDEC (HGNC Symbol)

Synonyms

 CIDE-3, FLJ20871, Fsp27

Description

 Cell death-inducing DFFA-like effector c (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 9866711 - 9880254

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187288 (version 83.38)

Entrez gene

 63924

UniProt

 Q96AQ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96AQ7

Antibodypedia

 CIDEC antibodies

PROTEIN BROWSER
CIDEC-001
CIDEC-002
CIDEC-003
CIDEC-004
CIDEC-006
CIDEC-201
CIDEC-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CIDEC-001
ENSP00000338642
ENST00000336832
Q96AQ7 [Direct mapping]
Cell death activator CIDE-3
A0A024R2F7 [Target identity:100%; Query identity:100%]
Cell death-inducing DFFA-like effector c, isoform CRA_a
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Show all
GO:0003674 [molecular_function]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0034389 [lipid particle organization]
GO:0042981 [regulation of apoptotic process]
GO:0097194 [execution phase of apoptosis]
Show all
 238 aa
26.8 kDa 		No 0
CIDEC-002
ENSP00000392975
ENST00000455015
Q96AQ7 [Direct mapping]
Cell death activator CIDE-3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Show all
GO:0003674 [molecular_function]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0034389 [lipid particle organization]
GO:0042981 [regulation of apoptotic process]
GO:0097194 [execution phase of apoptosis]
Show all
 164 aa
18.4 kDa 		No 0
CIDEC-003
ENSP00000400649
ENST00000423850
Q96AQ7 [Direct mapping]
Cell death activator CIDE-3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Show all
GO:0003674 [molecular_function]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0034389 [lipid particle organization]
GO:0042981 [regulation of apoptotic process]
GO:0097194 [execution phase of apoptosis]
Show all
 164 aa
18.4 kDa 		No 0
CIDEC-004
ENSP00000411356
ENST00000443115
A0A0C4DG75 [Direct mapping]
Cell death activator CIDE-3
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0006915 [apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 133 aa
14.5 kDa 		No 0
CIDEC-006
ENSP00000408631
ENST00000430427
Q96AQ7 [Direct mapping]
Cell death activator CIDE-3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Show all
GO:0003674 [molecular_function]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0034389 [lipid particle organization]
GO:0042981 [regulation of apoptotic process]
GO:0097194 [execution phase of apoptosis]
Show all
 248 aa
27.9 kDa 		No 0
CIDEC-201
ENSP00000373328
ENST00000383817
A0A0A0MRY9 [Direct mapping]
Cell death activator CIDE-3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0005811 [lipid particle]
GO:0006915 [apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 251 aa
28.3 kDa 		No 0
CIDEC-202
ENSP00000483641
ENST00000618572
Q96AQ7 [Direct mapping]
Cell death activator CIDE-3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Show all
GO:0003674 [molecular_function]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0034389 [lipid particle organization]
GO:0042981 [regulation of apoptotic process]
GO:0097194 [execution phase of apoptosis]
Show all
 248 aa
27.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.