Cell atlas - GJA4 - The Human Protein Atlas

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GJA4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	GJA4
Gene description	Gap junction protein, alpha 4, 37kDa
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (EFO-21)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	GJA4 (HGNC Symbol)
Synonyms	CX37
Description	Gap junction protein, alpha 4, 37kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	34792998 - 34795747
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187513 (version 83.38)
Entrez gene	2701
UniProt	P35212 (UniProt - Evidence at protein level)
neXtProt	NX_P35212
Antibodypedia	GJA4 antibodies

PROTEIN BROWSER

GJA4-001	GJA4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GJA4-001 ENSP00000343676 ENST00000342280	P35212 [Direct mapping] Gap junction alpha-4 protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0001568 [blood vessel development] GO:0003158 [endothelium development] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005921 [gap junction] GO:0005922 [connexon complex] GO:0006810 [transport] GO:0006816 [calcium ion transport] GO:0007043 [cell-cell junction assembly] GO:0007154 [cell communication] GO:0007267 [cell-cell signaling] GO:0048265 [response to pain] Show all	333 aa 37.4 kDa	No	4
GJA4-002 ENSP00000409186 ENST00000450137	Q5JW71 [Direct mapping] Gap junction protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005922 [connexon complex] GO:0007154 [cell communication] GO:0016021 [integral component of membrane] Show all	292 aa 32.9 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.