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IFT140

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GENERAL INFORMATION

Gene name

 IFT140

Gene description

 Intraflagellar transport 140

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 IFT140 (HGNC Symbol)

Synonyms

 gs114, KIAA0590, WDTC2

Description

 Intraflagellar transport 140 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 1510427 - 1612110

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187535 (version 83.38)

Entrez gene

 9742

UniProt

 Q96RY7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RY7

Antibodypedia

 IFT140 antibodies

PROTEIN BROWSER
IFT140-001
IFT140-006
IFT140-007
IFT140-011
IFT140-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFT140-001
ENSP00000406012
ENST00000426508
Q96RY7 [Direct mapping]
Intraflagellar transport protein 140 homolog
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006996 [organelle organization]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0021532 [neural tube patterning]
GO:0030991 [intraciliary transport particle A]
GO:0031513 [nonmotile primary cilium]
GO:0032391 [photoreceptor connecting cilium]
GO:0035108 [limb morphogenesis]
GO:0035721 [intraciliary retrograde transport]
GO:0035845 [photoreceptor cell outer segment organization]
GO:0036064 [ciliary basal body]
GO:0042073 [intraciliary transport]
GO:0042384 [cilium assembly]
GO:0048705 [skeletal system morphogenesis]
GO:0060041 [retina development in camera-type eye]
GO:0060271 [cilium morphogenesis]
GO:0061512 [protein localization to cilium]
GO:0072001 [renal system development]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
Show all
 1462 aa
165.2 kDa 		No 0
IFT140-006
ENSP00000354895
ENST00000361339
Q96RY7 [Direct mapping]
Intraflagellar transport protein 140 homolog
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005813 [centrosome]
GO:0005930 [axoneme]
GO:0006996 [organelle organization]
GO:0030991 [intraciliary transport particle A]
GO:0035721 [intraciliary retrograde transport]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
GO:0048705 [skeletal system morphogenesis]
GO:0060041 [retina development in camera-type eye]
GO:0061512 [protein localization to cilium]
GO:0072001 [renal system development]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
GO:1902017 [regulation of cilium assembly]
Show all
 656 aa
75.6 kDa 		No 0
IFT140-007
ENSP00000454781
ENST00000569646
H3BNC5 [Direct mapping]
Intraflagellar transport protein 140 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005930 [axoneme]
GO:0035721 [intraciliary retrograde transport]
GO:0042384 [cilium assembly]
Show all
 121 aa
13.4 kDa 		No 0
IFT140-011
ENSP00000458439
ENST00000568837
I3L0Y8 [Direct mapping]
Intraflagellar transport protein 140 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005930 [axoneme]
GO:0035721 [intraciliary retrograde transport]
GO:0042384 [cilium assembly]
Show all
 125 aa
14.5 kDa 		No 0
IFT140-012
ENSP00000457092
ENST00000569812
H3BTA5 [Direct mapping]
Intraflagellar transport protein 140 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005930 [axoneme]
GO:0035721 [intraciliary retrograde transport]
GO:0042384 [cilium assembly]
Show all
 113 aa
12.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.