Expression of TET3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Tet methylcytosine dioxygenase 3

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

HPA050845

GENE INFORMATION
Gene name	TET3 (HGNC Symbol)
Synonyms	hCG_40738, MGC22014
Description	Tet methylcytosine dioxygenase 3 (HGNC Symbol)
Entrez gene summary	Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	73986404 - 74108176
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187605 (version 83.38)
Entrez gene	200424
UniProt	O43151 (UniProt - Evidence at protein level)
neXtProt	NX_O43151
Antibodypedia	TET3 antibodies

PROTEIN BROWSER

TET3-001	TET3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TET3-001 ENSP00000386869 ENST00000409262	O43151 [Direct mapping] Methylcytosine dioxygenase TET3 K9JJH7 [Target identity:100%; Query identity:100%] Putative methylcytosine dioxygenase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001939 [female pronucleus] GO:0001940 [male pronucleus] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006493 [protein O-linked glycosylation] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0035511 [oxidative DNA demethylation] GO:0040029 [regulation of gene expression, epigenetic] GO:0044727 [DNA demethylation of male pronucleus] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0070579 [methylcytosine dioxygenase activity] GO:0080111 [DNA demethylation] GO:0080182 [histone H3-K4 trimethylation] Show all	1795 aa 193.7 kDa	No	0
TET3-004 ENSP00000307803 ENST00000305799	J3KNF3 [Direct mapping] Methylcytosine dioxygenase TET3 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		1702 aa 183.6 kDa	No	0