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TRPV2

GENERAL INFORMATION

Gene name

 TRPV2

Gene description

 Transient receptor potential cation channel, subfamily V, member 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA044993
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRPV2 (HGNC Symbol)

Synonyms

 VRL, VRL-1, VRL1

Description

 Transient receptor potential cation channel, subfamily V, member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 16415542 - 16437003

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187688 (version 83.38)

Entrez gene

 51393

UniProt

 Q9Y5S1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5S1

Antibodypedia

 TRPV2 antibodies

PROTEIN BROWSER
TRPV2-001
TRPV2-006
TRPV2-007
TRPV2-009
TRPV2-010
TRPV2-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPV2-001
ENSP00000342222
ENST00000338560
Q9Y5S1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 2
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0009266 [response to temperature stimulus]
GO:0009408 [response to heat]
GO:0009986 [cell surface]
GO:0015075 [ion transmembrane transporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030027 [lamellipodium]
GO:0030424 [axon]
GO:0032584 [growth cone membrane]
GO:0034220 [ion transmembrane transport]
GO:0042470 [melanosome]
GO:0044295 [axonal growth cone]
GO:0044297 [cell body]
GO:0045773 [positive regulation of axon extension]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0090280 [positive regulation of calcium ion import]
Show all
 764 aa
86 kDa 		No 6
TRPV2-006
ENSP00000390014
ENST00000455666
H7BZK2 [Direct mapping]
Transient receptor potential cation channel subfamily V member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0009408 [response to heat]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 266 aa
29 kDa 		No 0
TRPV2-007
ENSP00000464850
ENST00000577277
K7EIQ6 [Direct mapping]
Transient receptor potential cation channel subfamily V member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0009408 [response to heat]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 77 aa
8.4 kDa 		No 1
TRPV2-009
ENSP00000465609
ENST00000581560
K7EKG5 [Direct mapping]
Transient receptor potential cation channel subfamily V member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0009408 [response to heat]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 138 aa
15.6 kDa 		No 1
TRPV2-010
ENSP00000466130
ENST00000580788
K7ELL3 [Direct mapping]
Transient receptor potential cation channel subfamily V member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0009408 [response to heat]
GO:0016021 [integral component of membrane]
GO:0070588 [calcium ion transmembrane transport]
Show all
 96 aa
10.4 kDa 		No 1
TRPV2-011
ENSP00000467593
ENST00000577865
K7EPY7 [Direct mapping]
Transient receptor potential cation channel subfamily V member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0009408 [response to heat]
GO:0070588 [calcium ion transmembrane transport]
Show all
 90 aa
9.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.